macrogol solution klean-prep  (Klean Industries)

Journal: Frontiers in Pharmacology

Article Title: Comparative effectiveness of treatments for recurrent Clostridioides difficile infection: a network meta-analysis of randomized controlled trials

doi: 10.3389/fphar.2024.1430724

Figure Lengend Snippet: Main characteristics of studies included in the network meta-analysis.

Article Snippet: Van Nood-2013 , Open-label, randomized, controlled trial , Diarrhea (≥3 loose or watery stools per day for at least 2 consecutive days or ≥8 loose stools in 48 h) and a positive stool test for C. difficile toxin , 42 , Vancomycin (500 mg qid, 4 days), followed by bowel lavage with 4 L Macrogol solution (Klean-Prep) on final day of antibiotic treatment and subsequent infusion of FMT solution through a nasoduodenal tube the next day (n = 16) , Vancomycin (500 mg qid, 14 days) (n = 13), or vancomycin with bowel lavage on day 4 or 5 (n = 13) , Absence of diarrhea or persistent diarrhea explained by other causes, with three consecutive negative stool tests for C. difficile toxin , 10 weeks.

Techniques: Infection, Suspension, Enzyme Immunoassay, Polymerase Chain Reaction, Biomarker Discovery, Capsules, Neutralization, Enzyme-linked Immunosorbent Assay

Journal: United European Gastroenterology Journal

Article Title: A network meta-analysis of randomized controlled trials exploring the role of fecal microbiota transplantation in recurrent Clostridium difficile infection

doi: 10.1177/2050640619854587

Figure Lengend Snippet: Main characteristics of studies included in the network meta-analysis.

Article Snippet: Concerning quality, overall the RCTs were assessed at the low to moderate end of the rating scale mainly because of lack of blinding, as four out of six (67%) were unblinded (open label) and in addition were underpowered. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 1. caption a7 Flowchart of studies included in the network meta-analysis. table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Reference Year/Country Study type/ total no included patients Disease characteristics FMT donor/ delivery method Intervention/ no patients included Comparator/ no patients included Definition of cure Follow-up DFMT-related events 26 2013/ Netherlands RCT/ n = 42 CDI recurrence after adequate antibiotic treatment (vancomycin, metronidazole) Healthy volunteer/ nasoduodenal tube Vancomycin (500 mg qid, 4 days), followed by bowel lavage with 4 l Macrogol solution (Klean-Prep) on final day of antibiotic treatment and subsequent infusion of FMT solution ( n = 16) Vancomycin (500 mg qid, 14 days), or vancomycin with bowel lavage on day 4 or 5 ( n = 26) Absence of diarrhea, or persistent diarrhea explained by other causes, with three consecutive negative stool tests for C. difficile toxin 10 weeks Belching, nausea, abdominal cramps, diarrhea 27 2015/Italy RCT/ n = 39 Recurrent CDI after antibiotic treatment Healthy volunteer/ colonoscopy Vancomycin (125 mg qid, three days), followed by one or more infusions of feces (diluted in 500 ml sterile saline) ( n = 20) Vancomycin (125 mg qid, 10 days), followed by 125–500 mg/day every two to three days for at least three weeks ( n = 19) Disappearance of diarrhea, or persistent diarrhea explicable by other causes, with two negative stool tests for C. difficile toxin 10 weeks Diarrhea, bloating, abdominal cramps 28 2016/USA RCT/ n = 46 Recurrent CDI after antibiotic treatment Healthy volunteer/ colonoscopy 300 ml fecal suspension infused into terminal ileum or cecum ( n = 22) Autologous FMT: 300 ml fecal suspension from own stool infused into terminal ileum or cecum ( n = 24) Resolution of diarrhea without need for further anti-CDI therapy for eight weeks Eight weeks Αbdominal pain, bloating, nausea, vomiting, flatulence, anorexia, constipation, fatigue, diarrhea Four serious side effects reported, none directly related to FMT 29 2017/Canada RCT/ n = 30 Two or more recurrences of CDI; at least one treatment with oral vancomycin.

Techniques: Sterility, Saline, Suspension